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KMID : 0369820140440010023
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Jorunal of Korean Pharmaceutical Sciences
2014 Volume.44 No. 1 p.23 ~ p.32
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Interaction of terbinafine hydrochloride with nicotinamide in solution and solid state
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Aggarwal Amit Kumar
Jindal Punam
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Abstract
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The aim of present study was to study the interaction of terbinafine hydrochloride with nicotinamide in solution as well as solid state. Solid dispersions of terbinafine hydrochloride were prepared by fusion method using nicotinamide as carrier in different ratios. Phase solubility studies were carried out at three different temperatures and thermodynamic parameters like enthalpy change (ΔH), entropy change (ΔS) and free energy change (ΔG) were calculated. These formulations were further characterized in the solid state by differential scanning calorimetry, powder X-ray diffraction and Fourier transform infrared spectroscopy. Solubility and dissolution studies showed that nicotinamide increases the solubility and dissolution rate of terbinafine hydrochloride. Thermodynamic parameters and solid state studies confirmed the absence of any chemical interactions between terbinafine hydrochloride and nicotinamide. It is concluded that the mechanism for increase in solubility of terbinafine hydrochloride by nicotinamide is the water breaking properties of nicotinamide.
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KEYWORD
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Solid dispersion, Terbinafine hydrochloride, Nicotinamide, Thermodynamic parameters, Dissolution
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